Instrument Calibration Protocol of Auto Titrator (905 titrando)
| INSTRUMENT | Auto Titrator (905 titrando) |
| Refer SOP No. | |
| Model No. | 905 titrando |
| Instrument Code No. | |
| Make | Metrohm |
| Frequency | Quarterly “- 5 days” |
| Date of Calibration | |
| Next Due Date |
1. Calibration of pH glass electrode (Aqueous) :
[ Electrode ID :______________________ ]
| Date | Buffer | Potential value | Slope | pH of buffer 7.00 | Acceptance criteria |
| Slope should between 96-102% Buffer 7.00 pH – should between 6.75-7.25 | |||||
| — | — | — | — | ||
| — | — | — | — |
Conclusion: Calibration of pH glass electrode (Aqueous)Complies/Does not complies as per
Acceptance criteria.
2. Calibration of Non – aqueous electrode (LL Solvotrode) :
[Electrode ID: ______________________]
| Date | Buffer | Potential value | Potential Difference | Acceptance criteria |
| Potential difference should be greater than or equal to 150 mv. | ||||
| — | — | — |
3. Calibration of Burette :
a. Calibration of Burette for Karl Fisher – 10 ml :
Burette No. : _______________ Balance ID: _________________
| Cal. For (ml) | Wt. of Beaker (g) | Wt. of Beaker + water (g) | Difference in wt. (g) | Difference in terms of ml | Burette reading displayed (ml) | Error in ml | Error in % | Limit | Remarks |
| — | [A] | [B] | [C= B – A] | {C/0.9970} | — | — | — | — | — |
| 2 | ± 0.30 % | ||||||||
| 5 | ± 0.20 % | ||||||||
| 8 | ± 0.20 % | ||||||||
| 10 | ± 0.20 % |
Conclusion: Calibration of Burette for Karl fisher – 10 mlcomplies/Does not complies as per acceptance criteria.
b. Calibration of Burette for Non Aqueous (auto Titrator) – 20 ml :
Burette No. : _______________ Balance ID: ________________
| Cal. For (ml) | Wt. of Beaker (g) | Wt. of Beaker + Water (g) | Difference in wt. (g) | Difference in terms of ml | Burette reading displayed (ml) | Error in ml | Error in % | Limit | Remarks |
| — | [A] | [B] | [C= B – A] | {C/0.9970} | — | — | — | — | — |
| 2 | ± 0.30 % | ||||||||
| 5 | ± 0.20 % | ||||||||
| 8 | ± 0.20 % | ||||||||
| 10 | ± 0.20 % | ||||||||
| 20 | ± 0.15 % |
Conclusion: Calibration of Burette for Karl fisher – 20 mlcomplies/Does not complies as per acceptance criteria.
c. Calibration of Burette for Aqueous (auto Titrator) – 20 ml :
Burette No. : _______________ Balance ID: _________________
| Cal. For (ml) | Wt. of Beaker (g) | Wt. of Beaker + Water (g) | Difference in wt. (g) | Difference in terms of ml | Burette reading displayed (ml) | Error in ml | Error in % | Limit | Remarks |
| [A] | [B] | [C= B – A] | {C/0.9970} | ||||||
| 2 | ± 0.30 % | ||||||||
| 5 | ± 0.20 % | ||||||||
| 8 | ± 0.20 % | ||||||||
| 10 | ± 0.20 % | ||||||||
| 20 | ± 0.15 % |
Conclusion:
Calibration of Burette for Karl fisher – 20 mlcomplies/Does not complies as per acceptance criteria.
4. Performance Verification of double Pt. wire electrode (KF titration):
Electrode ID: _______________
Lot no. of Di-sodium Tartrate: ________________
| Date | Weight of Di-sodium Tartrate | Water content (%) | Acceptance Criteria |
| 15.66 ± 3% (15.190 – 16.130) | |||
| — | — |
Conclusion:
Performance Verification of double Pt. wire electrode (KF titration) complies/Does not complies as per acceptance criteria.
5. Standardization by Potentiometric :
Electrode ID: _______________
Lot no. of KHC8H4O4: ________________
| Sample ID | Weight of KHC8H4O4 | Normality (N) | Limit |
| 1 | N ± 5 % (0.0950 N – 0.1050 N) | ||
| 2 | — | ||
| 3 | — | ||
| — | % RSD | — | NMT 0.2 % |
Conclusion:
Standardization by potentiometric isComplies/does not complies as per acceptance
Criteria.
Remarks: Calibration Satisfactory / Not Satisfactory
| — | Calibrated By | Checked By | Approved By |
| Signature | |||
| Date | |||
| Name | |||
| Department | Quality Control | Quality Control | Quality Control |
