July 12, 2021: Pharmaceutical Interview Questions and Answers
What are the different types of tablet coating defects?
Blistering: Blistering meansblistering of a surface film appears when film becomes detached from the tablet’s substrate.
Chipping: Chipping means dented and chipped film mostly on the edges of the tablet.
Cratering: Cratering means volcanic like cratering happens exposing the tablet surface.
Sticking or Picking: Sticking or picking means sticking of film with each other or with the coating pan resulting to some of the tablet pieces being detached from the core.
Pitting: Pitting is the deformation of the core of the tablet without any visible signs of disruption of the film coating.
Blooming: Blooming is the fading or dulling of a tablet color after when it is stored for prolonged period at a high temperature.
Blushing: Blushing is described as appearance of white specks or a haziness in the film.
Color Variation: Color variation of tablet film.
Infilling: This refers to the filling of intagliations – i.e., the distinctive words or symbols formed on the tablet.
Orange Peel or Roughness: When film having a rough surface or have a matt surface rather than glossy texture. It appear same as an orange.
Cracking or Splitting: The cracking defect observes when the film coating of the tablet cracks in the crown area or splits around the edges.
Twinning: Twinning is when two tablets sticks together.
Erosion: Coating gets removed from the surface due to friction between tablets.
Bridging: When coating material fills in the the logo or letter, bridging occurs.