September 24, 2021: Pharmaceutical Interview Questions and Answers

#SampleNeutralization #WhatIsPyrogensAndEndotoxins #SourceOfPyrogensAndEndotoxins

1. What should be done during microbiology testing if sample exhibit antimicrobial activity?

When the sample possesses antimicrobial activity, it that requires neutralization. Following are commonly used principle for neutralization:

● Chemical neutralization

● Enzymatic neutralization

● Dilution

2. What is Pyrogens and endotoxins?

Pyrogens and endotoxins are a heterogeneous group of chemical entities that cause fever when injected.

3. What is the source of pyrogens and endotoxins?

Pyrogens can be nonbacterial as well as bacterial in origin.

In the pharmaceutical industry, mostly observed source is from Gram-negative bacteria. That is the lipopolysaccharide (LPS) from the bacterial cell wall.

Pyrogens are the metabolic byproduct of the Gram-negative bacteria.

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