Pharmaceutical Interview Questions and Answers

August 2, 2021: Pharmaceutical Interview Questions and Answers

#OperatingPrinciplesCoatingEquipment #EquipmentClassificationCoating

1. What are the Operating Principles of different equipment for coating?

Types of coatingDetails of Principles
Pan CoatingThe uniform deposition of coating material onto the surface of a solid dosage form, or component thereof, while being translated via a rotating vessel.
Gas SuspensionThe application of a coating material onto a solid dosage form, or component thereof, while being entrained in a process gas stream. Alternatively, this may be accomplished simultaneously by spraying the coating material and substrate into a process gas stream.
Vacuum Film CoatingThis technique uses a jacketed pan equipped with a baffle system. Tablets are placed into the sealed pan, an inert gas (i.e., nitrogen) is used to displace the air and then a vacuum is drawn.
Dip CoatingCoating is applied to the substrate by dipping it into the coating material. Drying is accomplished using pan coating equipment.
Electrostatic CoatingA strong electrostatic charge is applied to the surface of the substrate. The coating material containing oppositely charged ionic species is sprayed onto the substrate.
Compression CoatingThe division of a powder blend in which compression force is applied to form a single unit dose.

2. Equipment Classifications used for coating.

Equipment typeSub classification descriptionSub classification
Pan CoatingPan coating subclasses primarily are distinguished by the pan configuration, the pan perforations, and/or the perforated device used to introduce process air for drying purposes. Perforated coating systems include both batch and continuous coating processes.• Non-perforated (conventional) Coating System • Perforated Coating System
Gas SuspensionGas suspension subclasses primarily are distinguished by the method by which the coating is applied to the substrate.• Fluidized Bed with bottom spray mechanism • Fluidized Bed with tangential spray mechanism • Fluidized Bed with top spray mechanism • Fluidized Bed with Wurster column • Spray Congealing/Drying
Vacuum Film CoatingAlthough there may be differences in the jacketed pan, baffle system, or vacuum source, no vacuum film coating subclasses have been identified.No sub class
Dip CoatingBecause of the custom design associated with this class of coating, no dip 1013 coating subclasses or examples have been identified.No sub class
Electrostatic CoatingBecause of the custom design associated with this class of coating, no 1018 electrostatic coating subclasses or examples have been identified.No sub class
Compression CoatingRefer tablet press principle Unit Dosing section of previous post.No sub class

Source: fda.gov

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