July 22, 2021: Pharmaceutical Interview Questions and Answers
#TypesOfCoatingMachines #AdvantagesOfTabletCoatingProcess #DisadvantagesOfTabletCoatingProces #CoatingEquipmentParts #FluidBedDryerParts
1. What are the types of tablet Coating Machines available in the market?
• Standard Coating Pan
• Perforated Coating Pan
• Fluidized Bed Coater
2. What are the advantages of tablet coating process?
Following are the advantages of tablet coating:
• It enhances its appearance
• Easy to consume
• Minimizes the unpleasant colour, odour or taste of drug
• Identification
• Helps to reduces drug degradation by protecting it from environmental factors
• Facilitates the packing process
• Functional coating gives functional advantages like extended release, enteric release, prolonged release etc.
3. What are the disadvantages of tablet coating process?
Following are the disadvantages of tablet coating:
• Cost of operation, resources and material
• Equipment operation and maintenance cost
• May change tablet properties
• Residual solvent toxicity
• Waiting time between processes
• Increase process lead time
• Increase analysis load
4. Explain parts of tablet coating equipment or machine.
Following are the parts of tablet coating equipment or machine
• Perforated coating pan
• Baffles in coating pan
• Spray gun
• Spray pump e.g. Peristalsis pump, Diaphragm pump
• Electric Motors
• Air Handing unit for inlet air
o Inlet air blower
o Air Handing unit housing
o Primary filter (Washable)
o High temperature HEPA filter
o Inlet air temperature sensor
o Differential air pressure sensors across the above filters
• Ducting to supply air and exhaust air
• Control panel with PLC Control and HMI
• Exhaust air blower
• Dust collector or air Scrubber (Wet or Dry)
• Solution preparation tank
5. Explain parts of Fluid bed dryer and Fluid bed processor?
Following are the parts of Fluid bed dryer and Fluid bed equipment
• Plenum
• Product Container with PU wheel trolley
• Inflatable gasket for connection between plenum and Product Container, and Product Container and expansion chamber
• Product temperature sensor
• Inlet air temperature and RH sensor
• Damper for inlet air
• Sample collection port in Product Container
• Glass view in Product Container
• Silicon molded Dutch Woven sieves
• Conidur mesh for mechanism of vortex formation
• Expansion chamber
• Glass view in Expansion chamber
• Finger bag
• Finger bag mounting assembly
• Finger bag shaking assembly
• Inflatable gasket to seal finger bag assembly
• Broken Bag Detector (BBD) sensor OR Solid Flow Monitor (SFM) sensor
• Exhaust blower
• Exhaust filters (10 and 3 µm porosity)
• Explosion flap and Explosion port
• Inlet Air Handling Unit
o Air Handing unit housing
o Primary filter (Washable)
o High temperature HEPA filter
o Dew point sensor
o Differential air pressure sensors across the above filters
o Damper
• CFM or Air flow sensor
• Inlet air duct
• Clean in place system
• Differential pressure sensors, across filters, across finger bag, across product container
• Exhaust air temperature
• Spraying system (for top spray granulation)
